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When considering the initiation of these therapies, it is important to consider patient-specific factors

The transport of fat into the mitochondria is aided by L-carnitine

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Role of GLP-1 agonists in managing comorbidities in HFpEF Beyond their cardioprotective properties, GLP-1 receptor agonists exert a beneficial impact on HFpEF by influencing other organ systems and mitigating comorbid conditions that contribute to its progression, including metabolic dysfunction-associated steatotic liver disease (MASLD), chronic kidney disease, and pulmonary disorders

In short, semaglutide nudges these systems through metabolic change rather than acting like a thyroid or sexhormone agent

Villani et al